Manchester United manager Ole Gunnar Solskjaer is expected to recall David De Gea for the game against Brighton despite Dean Henderson impressing against Luton midweek.
In defence, Aaron Wan-Bissaka will likely start his first Premier League game of the season, in place of Timothy Fosu-Mensah, with Victor Lindelof, Harry Maguire and Luke Shaw making up the rest of the backline.
Donny van de Beek could be in line for his full Premier League debut at the Amex, so he could come in for Scott McTominay, to play alongside Paul Pogba, with Bruno Fernandes playing in the most advanced midfield position.
After scoring as a substitute versus Luton in the Carabao Cup, Mason Greenwood will almost certainly replace Daniel James on the right-wing, with Marcus Rashford playing off the left flank and Anthony Martial taking up the number nine role.
Manchester United’s Predicted XI To Face Brighton:
De Gea, Wan-Bissaka, Lindelof, Maguire, Shaw, van de Beek, Fernandes, Pogba, Greenwood, Martial, Rashford