Manchester United take on Championship side Bristol City in the Carabao Cup quarter-final on Wednesday night, followed by a trip to Leicester on Saturday in the Premier League.
It marks the beginning of the Red Devils’ festive fixtures, where teams are expected to face injury hits and fatigue.
However, for once it seems United don’t have too much to be concerned about, and have a number of stars look set to return to action.
Mourinho is likely to rotate his squad against Bristol City after beating West Brom on Sunday, with the likes of Paul Pogba set to return from his ban while Zlatan Ibrahimovic could be in line to start his first game of the season.
And although Sergio Romero will more than likely start in goal for the game, he is almost certainly going to have to give way to De Gea against Leicester.
Henrikh Mkhitaryan, whose future to the club has plenty of question marks surrounding it, should return to action this week.
Injury-wise United will be without Marourane Fellaini, who is suffering a knee injury, Eric Bailly and Michael Carrick.
There is also concern over Antonio Valencia, who hobbled off against West Brom holding his hamstring.
Mourinho admitted he didn’t know too much about the injury, calling it a ‘December injury’.
“The Valencia injury is what I call a December injury. It is an injury of the accumulation of fatigue. It is a muscular one – hamstring, big small, medium? I don’t know,” said Jose.
“He is an experienced guy to not let it go to difficult limits. But it is an injury of fatigue – everyone in the Premier League, especially the ones with more accumulation of cups and European cups – are at risk.”
[Quotes via Mirror]