Casemiro
The midfielder will have the shortest turnaround time of any player in Man United’s squad ahead of the Man City fixture.
Brazil take on Chile early on Friday morning UK time before travelling to face Bolivia in La Paz at 12:30 AM (BST) on Wednesday.
Amad
Ivory Coast host Burundi in a World Cup qualifier on Friday night, and they then fly to Gabon next week for a match on Tuesday evening.
When you take into account travel times back to the UK, Amad may only be back in training at Carrington on Thursday next week.
Matthijs De Ligt
The centre-back host Poland tonight (Thursday 4th September) before taking on Lithuania away from home in their second World Cup qualifier on Sunday.
That means de Ligt will be among the most rested of any of the players called up for international duty ahead of the derby.
Benjamin Sesko
The striker will be keen to build up his fitness and confidence whilst he is away with his country.
Slovenia take on Sweden at home on Friday night before travelling to face Switzerland in Basel on Monday.